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在CNP类似物赛道，Ascendis的TransCon-CNP率先实现了剂型升级。与Vosoritide不一样的设计是TransCon-CNP被一层保护分子包裹，降低了体内清除影响，延长作用时间，实现每周一次给药。非头对头临床数据显示，TransCon-CNP每年2.29厘米的增高表现也优于Vosoritide。
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One by-product of weighing the candidates by their distance is that the resulting output image is prone to false contours or banding. Increasing reduces this effect at the cost of added granularity or high frequency noise due to the introduction of ever more distant colours to the set. I recommend taking a look at the original paper if you’re interested in learning a bit more about the algorithm[1].
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phase[classno] = 2;